A group led by Frederick Alt, developed a technology to greatly speed up HIV development in mice. The group’s method generates mouse models with built-in human immune systems. The model rapidly recapitulates what the human immune system does, enabling researchers to continuously test and tweak potential HIV vaccines.
The Winau Lab has discovered a new mechanism for skin inflammation. This work, recently published in Nature Immunology, forms the basis for future therapeutic strategies against inflammatory skin diseases, such as poison ivy dermatitis and psoriasis.
Reporting this week in Nature, scientists in Boston Children’s Hospital’s Program in Cellular and Molecular Medicine (PCMM) describe new potential avenues for controlling both sepsis and the runaway bacterial infections that provoke it.
Now, a research team led by Wesley Wong has made a major advance by developing an inexpensive method that permits analysis of the force responses of thousands of similar molecules simultaneously.
Study reveals new avenue for thinking about brain development, brain tumors and neurodevelopmental/psychiatric diseases
Over the last couple of years Judy Lieberman’s lab has uncovered evidence for what could be an evolutionarily ancient form of immune defense directed against intracellular pathogens. In a 2014 Cell paper, her lab revealed that the immune system’s T-cells can kill intracellular bacteria directly by pummeling infected cells with three proteins: perforin, granulysin and granzymes
In a recent Cell paper, a team led by Hao Wu, PhD, used electronic microscopy to reveal how RAG1 and 2 interact at a structural level, both with each other and with DNA.
Researchers in Dr. Fred Alt's laboratory used a novel in vivo mouse model system to resolve longstanding questions regarding the influence of DNA sequences on AID targeting and mutational outcomes during antibody diversification.
In a new paper in Cell Stem Cell, Dr. Yi Zhang's team report that they’ve extended their work to improve the efficiency of SCNT in human cells.
A study, reported in Cell, of where and how an enzyme cuts DNA may have inadvertently revealed a basic principle of gene regulation. This study suggests that the cell can lock or "sandbox" genes and enzymes that act on them within loops of DNA and protein, confining their activity to minimize the risk of genetic disaster.
A team in Frederick Alt's laboratory, led by Junchao Dong, Rohit A. Panchakshari, and Tingting Zhang, have made important strides towards resolving a long-standing question about how different classes of antibodies are made.
Delayed wound healing in people with type 1 or 2 diabetes can be caused by complications such as reduced blood flow, neuropathy and impaired signaling between cells. According to research by Denisa Wagner, PhD, a poorly understood feature of our immune system’s neutrophils may be one more ingredient in the storm.
An 880-pound digital media sculpture, "Absorption", by artist Rudolfo Quintas, is the result of discussions had with Dr. Tomas Kirchhausen, Principal Investigator in the Program in Cellular and Molecular Medicine at Boston Children’s Hospital and Professor Cell Biology at Harvard Medical School, regarding the essential cellular process of endocytosis.
Millions of people worldwide suffer from co-infection with tuberculosis (TB) and HIV. While prompt antibiotic and antiretroviral treatment can be a recipe for survival, over the years, physicians have noticed something: two or three weeks after starting antiretrovirals, about 30 percent of co-infected patients get worse.
Not all cancer cells are created equal. To call a cancer a cancer, in the singular, is something of a misnomer. A patient could be said to have cancers, as every tumor is actually a mixture of cells with different mutations and capabilities. One of those capabilities is the ability to escape the main tumor and spread, or metastasize, to other sites in the body.
Life teems with interactions. Proteins bind. Bonds form between atoms, and break. Enzymes cut. Drugs attach to cell receptors. DNA hybridizes. Those interactions make the processes of life work, and capturing them has led to many medical advances.
An AIDS vaccine able to fight any HIV strain has thus far eluded science. HIV frequently mutates its coat protein, dodging vaccine makers’ efforts to elicit sufficiently broadly neutralizing antibodies.
Yet sometimes HIV-infected people can produce such antibodies on their own. This usually requires years of exposure to the virus, allowing the immune system to modify its antibodies over time to keep up with HIV mutations. But the goal is generally achieved too late in the game to prevent them from being infected.
“Only a small fraction of patients are able to develop broadly neutralizing antibodies, and by the time they do, the virus has already integrated into the genomes of their T-cells,” says Ming Tian, PhD, of Boston Children’s Hospital’s Program… Read More »
During this fellowship Dr. Lee will investigate how recombination activating gene endonuclease (RAG) mediates recombination between bona fide RAG recognition sequences (RRSs). Specifically,… Read More »
Dr. Beerman, an Instructor in Pediatrics in Dr. Derrick Rossi's laboratory, has received a five-year career development award to establish the potential of aged blood cells to be reprogrammed to cells… Read More »